Tetrahydrothiophene-3-one industry outlook is not optimistic due to increasingly stringent environmental policies

5,6,7,7a-tetrahydrothieno(3,2-c)pyridine-2(4h)-one hydrochloride is used as the intermediate of Prasugrel.
　　Prasugrel is a thiophenopyridine antiplatelet developed by Eli Lilly and daiichisankyo, a Japanese pharmaceutical manufacturer. It is a precursor drug. It forms an active molecule after metabolism through cytochrome P450 in the liver and combines with platelet P2Y12 receptor to exert an active against platelet aggregation. Clinical studies have proved that 60 mg dose has better anticoagulant effect than 300 mg standard dose and 600 mg increased dose of clopidogrel, which can reduce the comprehensive risk of heart attack, stroke and death due to heart disease by 20%, and has fast effect, good curative effect, good drug resistance and bioavailability, and low toxicity.

　　Tetrahydrothiophene-3-one is a colorless to light yellow liquid with onion and garlic, meat, vegetable and cream like aroma, mostly used as a food additive, the use limit in soft drinks, cold drinks, candy, jelly, pudding, gummi candy, seasonings, marinades, meat products, meat soup soup, milk and dairy products, cereal products and other products are 1.0mg/kg.
　　The synthesis routes of tetrahydrothiophene-3-one are mainly as follows.
　　Paul Karrer et al. disclosed a method for the synthesis of tetrahydrothiophen-3-one in U.S. patent US2408518, granted in 1946. The applicant used 1-chloro-4-iodobutanone to obtain the target product by direct ring formation reaction with sodium sulfide. This method is costly and involves difficult preparation of the raw material 1-chloro-4-iodobutanone, which cannot meet the requirements of industrial production.
　　European patent EP0127121 also reported a method for the synthesis of tetrahydrothiophen-3-one, which is based on thioglycolic acid and acrylic acid as starting materials, and Michael addition product is obtained under the catalysis of ammonium acetate, cyclized under the action of barium hydroxide, and then decarboxylated at high temperature. This route is shorter, but has several shortcomings: the reaction uses a large amount of barium hydroxide, which is bound to produce highly toxic barium salts, and generates a large amount of black polymer, which is not easy to handle and brings great harm to the environment; and the high temperature condition of 250℃ is too harsh in production.
　　In China, the currently disclosed synthesis method is a tetrahydrothiophen-3-one preparation method invented by Jiang Chen, Tang Qiming, Guo Ziwei, Zhou Xudong, etc., which is obtained by a four-step reaction of ethylene addition, carbonyl protection, cyclization and deprotection using chloroacetyl chloride as the starting material. The method has the advantages of novel design, high yield, low cost and easy availability of raw materials, and is safe and simple to operate and suitable for industrial production.
　　In recent years, the technology of tetrahydrothiophen-3-one industry in China has been refined, the synthesis route has been improved, and the industry has been developing and maturing, but most of the tetrahydrothiophen-3-one manufacturers are small and medium-sized enterprises with backward equipment. At the same time, the preparation of tetrahydrothiophen-3-one uses chloroacetyl chloride as the starting material, which can produce a lot of pollution in production. With the tightening of environmental protection, the development of China's tetrahydrothiophen-3-one industry is also facing challenges.
　　The "2017-2022 China Tetrahydrothiophene-3-one Industry Market Research Report" released by Newscorp Industry Research Center shows that tetrahydrothiophene-3-one is one of the many flavor and fragrance additives, which is a relatively niche additive with a relatively small market size. the market size of tetrahydrothiophene-3-one in China was only 0.16 billion yuan in 2016. And there are more substitutes for tetrahydrothiophene-3-one, and the market demand is low and the growth momentum is insufficient. Due to the small market size and environmental protection and other factors, it is difficult for companies to form large-scale production and effectively reduce production costs. Some tetrahydrothiophen-3-one enterprises have an annual output of only a few hundred kilograms.
　　The production process of tetrahydrothiophene-3-one products is more polluting to the environment, and under the current increasingly tense environmental situation, many small and medium-sized enterprises choose to shut down production, or switch to the production of other categories of fragrance and flavor additives, whose output also fell from 22 tons in 2011 to 20 tons in 2016. The decline in production led to a tight market supply, coupled with the impact of factors such as increased environmental protection costs, the price of tetrahydrothiophene-3-one products in China rose all the way to 837,000 yuan/ton in 2016.
　　According to the researcher of Xinshiwei Industry Research Center, the development prospect of tetrahydrothiophene-3-one industry is not optimistic. 2017-2022, the market size of tetrahydrothiophene-3-one will show a slow growth, with the growth rate remaining between 2.2% and 3.6%.
　　Currently, due to the impact of environmental protection and rising production costs, China's tetrahydrothiophene-3-one manufacturers have decreased, and market concentration has increased. 2017-2022, the survival pressure on tetrahydrothiophene-3-one companies will continue to increase, coupled with the fierce competition in the food spice sector, will prompt small-scale enterprises to gradually exit the market, tetrahydrothiophene-3-one market concentration will continue to increase The market concentration of tetrahydrothiophene-3-one will continue to increase.

PRODUCT TAGS

5,6,7,7a-Tetrahydro-thieno[3,2-c]pyridin-2(4H)-oneHydrochloride;5,6,7,7a-Tetrahydro-thieno[3,2-c]pyridinoneHydrochloride;5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-onehydrochloride;2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridineChemicalbook.Hydrochloride;5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2(4H)-oneHCL;5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-onehydrochlorideprasugrelintermediateI;5,6,7,7a-Tetrahydro-4H-thieno[3,2-c]2-pyridonehydrochloride;Pragraelintermediate